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Sterilizing immunity in the lung relies on targeting

fungal apoptosis-like programmed cell death

 

Shlezinger N, Irmer H, Dhingra S, et al. Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death. Science. 2017;357(6355):1037-1041. doi:10.1126/science.aan0365

Mitochondrial Reactive Oxygen Species Enhance Alveolar Macrophage Activity against Aspergillus fumigatus but Are Dispensable for Host Protection
Shlezinger N and Hohl TM.(2021). Msphere 6.3 (2021): e00260-21.

Fungal Bioreporters to monitor outcomes of Aspergillus – host cell interactions

 

Shlezinger N, Fites JS, Klein BS, Hohl TM.(2019). ‘Fungal Bioreporters to monitor outcomes of Aspergillus – host cell interactions. Host-fungal interactions: Methods and protocols. Springer, Boston, MA.

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Figure S10. A model showing the role of
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Translocation from nuclei to cytoplasm is necessary for anti A-PCD activity and turnover
of the Type II IAP BcBir1

Shlezinger, N., Israeli, M., Mochly, E., Oren‐Young, L., Zhu, W., & Sharon, A. Molecular microbiology, 99(2), 393-406.

Fungi Infecting Plants and Animals: Killers,

Non-Killers, and Cell Death

  Sharon A, Shlezinger N (2013). Fungi Infecting Plants and Animals: Killers, Non-Killers, and Cell        Death. PLoS Pathog 9:e1003517.

Measurement of apoptosis by SCAN©, a system for counting and analysis of fluorescently labelled nuclei

Shlezinger, N., Eizner, E., Dubinchik, S., Minz-Dub, A., Tetroashvili, R., Reider, A., & Sharon, A. (2014). Measurement of apoptosis by SCAN©, a system for counting and analysis of fluorescently labelled nuclei. Microbial Cell, 1(12), 406.

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Anti-apoptotic machinery protects the necrotrophic fungus Botrytis cinerea from host- induced apoptotic-like cell death during plant infection

Shlezinger N, Minz A, Gur Y, Hatam I, Dagdas YF, Talbot NJ, Sharon A (2011). Anti-apoptotic machinery protects the necrotrophic fungus Botrytis cinerea from host- induced apoptotic-like cell death during plant infection. PLoS Pathog 7:e1002185.

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Apoptosis-like programmed cell death in the grey
mould fungus Botrytis cinerea: genes and their
role in pathogenicity

Shlezinger N, Doron A, Sharon A (2011).  Biochem Soc Trans 39:1493-1498.

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Fungal apoptosis: function, genes and gene function

 

Sharon A, Finkelstein A, Shlezinger N, Hatam I (2009). Fungal apoptosis: function, genes and gene function. FEMS Microbiol Rev 33:833-854.  

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Botrytis cinerea BcNma is involved in apoptotic cell death but not in stress adaptation

 

Finkelshtein A, Shlezinger N, Bunis O, Sharon A (2011). Botrytis cinerea BcNma is involved in apoptotic cell death but not in stress adaptation. Fung Genet Biol 48:621-630. 

Apoptotic-like programed cell death in fungi: the benefits in filamentous species

 Shlezinger N, Goldfinger N, Sharon A. Apoptotic-like programed cell death in fungi: the benefits in filamentous species. Front Oncol. 2012 Aug 7;2:97. doi: 10.3389/fonc.2012.00097. PMID: 22891165; PMCID: PMC3412994